Redox Mechanism of Neurotoxicity by a Serotonin–Acrolein Polymeric Melanoid
Document Type
Article
Publication Title
Neurotoxicity Research
Abstract
Postoperative cognitive dysfunction may be associated with the toxic products of lipid peroxidation, such as the α,β-unsaturated aldehyde acrolein, which accumulates in aging. We previously identified an acrolein-mediated, serotonin-derived melanoid product, or SDM. This study further characterizes this putative novel neuromelanin, which is not made from catecholamines. In addition to its strong protein-binding properties, we observed that SDM binds Fe(2+) readily and exhibits complex redox characteristics. SDM may exist as a two-dimensional network of polymers that coalesce into larger entities exhibiting electroactive properties. These observations suggest that SDM may contribute to the decline in cognition due to focal degeneration from SDM-mediated free-radical production. We know that inhalational anesthetics sequester acrolein, which is toxic to neurons, and we propose that the local increase in acrolein depletes serotonin levels and enhances neuronal vulnerability through the production of neuromelanin-like structures, such as SDM.
DOI
10.1007/s12640-010-9173-3
Publication Date
2-2011
Keywords
Acrolein, Inhaled anesthetics, Neuromelanin, Postoperative cognitive dysfunction, Serotonin
ISSN
1476-3524
Recommended Citation
Murphy MM, Miller ED, Fibuch EE, Seidler NW. Redox Mechanism of Neurotoxicity by a Serotonin–Acrolein Polymeric Melanoid. Neurotoxicity Research. 2011; 19(2). doi: 10.1007/s12640-010-9173-3.
