Production of a Novel Neuromelanin at the Sevoflurane-Water Interface
Document Type
Article
Publication Title
Biochemical and Biophysical Research Communications
Abstract
Postoperative cognitive dysfunction (POCD) occurs in the elderly following surgery that requires inhaled anesthetics. The molecular mechanism associated with this process is unknown. This study examined the possible role of serotonin, a neurotransmitter involved in cognition. We observed that sevoflurane, a common inhaled anesthetic, formed a separate phase in water similar to that of chloroform. Additionally, sevoflurane sequestered acrolein, which is a lipid peroxidation product associated with aging and is elevated in the elderly brain. The enhanced partitioning of acrolein increased the focal concentration and hence reactivity to serotonin which preferentially occurred at the sevoflurane-water interface. The resulting product exhibited unique properties similar to catecholamine-derived neuromelanin.
DOI
10.1016/j.bbrc.2007.08.150
Publication Date
11-9-2007
Keywords
Acrolein, Neuromelanin, Serotonin, Sevoflurane
ISSN
1090-2104
Recommended Citation
Roberts R, Fibuch EE, Heal E, Seidler NW. Production of a Novel Neuromelanin at the Sevoflurane-Water Interface. Biochemical and Biophysical Research Communications. 2007; 363(1). doi: 10.1016/j.bbrc.2007.08.150.
