GAPDH: Biological Properties and Diversity
Document Type
Book
Publication Title
Advances in Experimental Medicine and Biology, Vol. 985
Abstract
The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.
DOI
10.1007/978-94-007-4716-6
Publication Date
2012
Keywords
Apoptosis, Cancer, Glyceraldehyde 3-Phosphate dehydrogenase, Inhaled Anesthetics, Neurodegeneration
ISBN
978-94-007-4715-9
Publisher
Springer
Edition
1
Recommended Citation
Seidler NW. GAPDH: Biological Properties and Diversity. Advances in Experimental Medicine and Biology, Vol. 985. 2012; 985. doi: 10.1007/978-94-007-4716-6.
