Dermatology Online Journal
Perivascular epithelioid cell tumors, also known as PEComas, are mesenchymal neoplasms which uncommonly originate within the skin, with only 23 cases documented within the literature. These rare neoplasms classically display epithelioid cells composed of granular or clear cytoplasm arranged in sheets, nests, or cords. Their immunoreactivity for melanocytic and smooth muscle markers makes these tumors distinct and unigue. We herein present two cases of primary cutaneous PEComas that clinically mimic other common cutaneous neoplasms and illustrate the necessity for clinical-pathologic correlation. A literature review is also presented to compare the different clinical and histological presentations of cutaneous PEComas.
Epithelioid cell, Mesenchymal neoplasm, PEComa, Perivascular epithelioid cell tumor
Wong J, Mammino J, Seyffert J, Schmits K, Marks E, Rivlin D. Primary Cutaneous Perivascular Epithelioid Cell Tumors: Two Cases and a Review of the Literature. Dermatology Online Journal. 2021; 27(10). doi: 10.5070/D3271055626.