Document Type

Article

Publication Title

Cureus

Abstract

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease of unknown origin. As with other vaccines, COVID-19 vaccines have been associated with many cutaneous reactions. Although COVID-19 vaccination is crucial, it is important for dermatologists and other physicians to be aware of the possible cutaneous reactions that can occur following COVID-19 vaccination. In this report, we describe a 73-year-old woman with a personal history of PG who experienced a recurrence after receiving her second dose of the tozinameran vaccine. Although extremely rare, flares of other inflammatory dermatoses, including lichen planus, have been reported following COVID-19 vaccination. Here we discuss the overlap in pathogenesis of PG and COVID-19, proposing possible mechanisms behind this rare phenomenon.

DOI

10.7759/cureus.22625

Publication Date

2-26-2022

Keywords

COVID-19 vaccine, inflammatory mediators, nonhealing ulcer, pyoderma gangenosum, recurrence COVID-19

ISSN

2168-8184

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