Malignancy-Associated Acquired Vulvar Lymphangioma Circumscriptum: A Clinicopathologic Study of 71 Cases
Document Type
Article
Publication Title
Journal of Cutaneous Pathology
Abstract
Background: Acquired lymphangioma circumscriptum of the vulva is rare and can occur subsequent to malignancies of the anogenital and pelvic region. We sought to investigate the clinicopathologic characteristics of malignancy-associated acquired vulvar lymphangioma circumscriptum (AVLC).
Methods: We identified all cases of AVLC within our institution with history of prior malignancy between 2005 and 2021. A similar search was performed in the PubMed database to identify published cases to date. The clinical and histopathologic information was recorded.
Results: A total of 71 cases were identified. The most common preceding malignancy was cervical carcinoma (71.8%, 51/71). Radiation therapy was given to 91.4% (64/70) of the patients and lymph node dissection was made on 70.2% (40/57). Median interval between the diagnosis of malignancy and the AVLC was 10 years (range 0-32 years). AVLC frequently presented as vesicular (31.6%, 18/57) or verrucous (28.1%, 16/57) lesions clinically. Common treatments for AVLC included excision (53.1%, 26/49) and laser therapy (16.3%, 8/49), with an overall recurrence rate of 42.9% (24/56) at a median follow-up interval of 1.8 years (range 0.04-32.3 years).
Conclusion: AVLC is a rare, late complication of anogenital and pelvic malignancies causing debilitating physical symptoms and psychological stress. Further studies are warranted to determine the most effective treatment modalities to mitigate recurrence.
DOI
10.1111/cup.14181
Publication Date
5-2022
Keywords
acquired vulvar lymphangioma, lymphangiectasia, lymphatic malformation
ISSN
1600-0560
Recommended Citation
Luu YT, Kimmis BD, Bodine JS, Gloyeske NC, Dai H. Malignancy-Associated Acquired Vulvar Lymphangioma Circumscriptum: A Clinicopathologic Study of 71 Cases. Journal of Cutaneous Pathology. 2022; 49(5). doi: 10.1111/cup.14181.
