Gamma-Delta and CD20 Mycosis Fungoides: Two Cases Uncovered by Broad-Spectrum Immunostaining
Document Type
Article
Publication Title
American Journal of Dermatopathology
Abstract
Mycosis fungoides (MF) expresses T-cell markers and the alpha-beta T-cell receptor (TCR) complex. Here, we describe a case of MF with dual expression of TCR delta and TCR beta and a case of MF expressing the B-cell marker CD20. Both anomalies were detected after we instituted a broad-spectrum immunostaining panel for cutaneous T-cell lymphomas. These findings suggest anomalous immunophenotypes may be more common in MF than previously appreciated. Histopathologists should be aware of unexpected malleability in the immunophenotype of MF to avoid confusion with other subtypes of cutaneous lymphoma. Further research into the prevalence and significance of CD20 and TCR-delta expression in MF is encouraged.
DOI
10.1097/DAD.0000000000002056
Publication Date
12-1-2021
Keywords
mycosis fungoides, lymphoma, T cell, cutaneous, receptors, antigen, prognosis
ISSN
1533-0311
Recommended Citation
Patel P, Fraga GR. Gamma-Delta and CD20 Mycosis Fungoides: Two Cases Uncovered by Broad-Spectrum Immunostaining. American Journal of Dermatopathology. 2021; 43(12). doi: 10.1097/DAD.0000000000002056.
