An 83-year-old Caucasian male presented with a history of asymptomatic yellow-orange macules and plaques concentrated on his trunk and proximal extremities that have been slowly progressing for the past three years. A punch biopsy revealed the presence of eosinophilic amorphous and fissured material within the superficial and interstitial dermis consistent with nodular amyloidosis. With the lack of concurrent systemic symptoms and negative systemic laboratory workup, the patient was diagnosed with disseminated primary localized cutaneous nodular amyloidosis (PLCNA). Due to the possibility of developing systemic progression, serial monitoring was recommended. This case highlights an under-reported and unusual presentation of a widely distributed form of PLCNA compared to the more common localized nodular and plaque variants.
amyloidosis, dermatology, disseminated primary localized cutaneous nodular amyloidosis, nodular amyloidosis, primary cutaneous amyloidosis
Niemann A, Mammino J, Nathoo R, Burger R. Multiple Indolent Asymptomatic Yellow-Orange Patches and Plaques. Cureus. 2022; 14(2). doi: 10.7759/cureus.21870.