Human Herpesvirus-6 Encephalitis Following Chemotherapy Induction for Acute Myelogenous Leukemia
Transplant Infectious Disease
We report a case of human herpesvirus-6 (HHV-6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad-spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Electroencephalogram and magnetic resonance imaging of the brain were unremarkable. Following diagnosis, the patient was successfully treated with ganciclovir. HHV-6 encephalitis should be considered in immunocompromised patients who become encephalopathic.
acute myelogenous leukemia, encephalitis, human herpesvirus-6, immunocompromised
Frey JW, Cherabie JN, Assi MA. Human Herpesvirus-6 Encephalitis Following Chemotherapy Induction for Acute Myelogenous Leukemia. Transplant Infectious Disease. 2017; 19(6). doi: 10.1111/tid.12756.