Urea as Safe Treatment for Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone in Infant With Solitary Central Incisor and Neurofibromatosis-1
Document Type
Article
Publication Title
Journal of Pediatric Endocrinology and Metabolism
Abstract
Objectives: Classic treatment for syndrome of inappropriate antidiuretic hormone (SIADH) is fluid restriction. However, this is not ideal for infants who need large fluid volumes to ensure adequate caloric intake for growth. The use of urea has not been thoroughly studied in children.
Case presentation: This infant had SIADH complicated by poor growth, solitary central incisor, and NF1. Following failed attempts to correct hyponatremia with fluid restriction and other therapeutics, urea normalized sodium levels and allowed liberalization of formula volumes, which resulted in improved weight gain.
Conclusions: Urea is a safe, cost-effective, long-term treatment for SIADH in infants who are unable to fluid restrict due to caloric goals.
DOI
10.1515/jpem-2022-0294
Publication Date
11-24-2022
Keywords
SIADH, solitary central incisor, urea
ISSN
2191-0251
Recommended Citation
Cui J, Halpin K, Paprocki E. Urea as Safe Treatment for Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone in Infant With Solitary Central Incisor and Neurofibromatosis-1. Journal of Pediatric Endocrinology and Metabolism. 2022; 36(4). doi: 10.1515/jpem-2022-0294.
