Pathogenic Involvement of Neuropeptides in Anxiety and Depression

Document Type

Article

Publication Title

Neuropeptides

Abstract

Anxiety and depression are highly prevalent disorders of mood posing significant challenges to individuals and society. Current evidence indicates no single neurobiological determinant underpins these conditions and an integrated approach in both research and treatment is expedient. Basic, behavioral, and clinical science indicates various stress-responsive neuropeptides in the neuroendocrine, autonomic, and behavioral pathophysiology of stress-related disorders including anxiety and depression. This review draws on recent research to capture the consensus and implications of neuropeptide research concerning the pathogenesis of anxiety and depression.

DOI

10.1016/j.npep.2009.12.014

Publication Date

6-2010

ISSN

1532-2785

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