Clinicopathologic Features and Outcomes of Lymphoplasmacytic Lymphoma Patients With Monoclonal IgG or IgA Paraprotein Expression

Document Type

Article

Publication Title

Leukemia & Lymphoma

Abstract

Lymphoplasmacytic lymphoma secreting IgG or IgA (non-IgM LPL) is rarely seen. Systematic studies of the clinical features and treatment outcomes are lacking in these patients. This study evaluated 17 patients with non-IgM LPL. The paraprotein secreted by these tumors was IgA (n=8; 47%) and IgG (n=9; 53%). The median serum level of paraprotein was 2,475 mg/dl (range=747-5260) for IgA and 2580 mg/dl (range=1900-7100) for IgG. The IgA-LPL group was more likely to present with B symptoms, a high beta2-microglobulin level and extramedullary involvement. Compared with patients with Waldenström macroglobulinemia (WM), patients with non-IgM LPL showed similar clinical and pathologic features, but a higher mortality within the first year after diagnosis (p

DOI

10.3109/10428194.2015.1096357

Publication Date

5-2016

Keywords

IgA, IgG, Lymphoplasmacytic lymphoma, Waldenström macroglobulinemia, non-IgM, prognosis, treatment

ISSN

1029-2403

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