Aβ-Polyacrolein Aggregates: Novel Mechanism of Plastic Formation in Senile Plaques
Document Type
Article
Publication Title
Biochemical and Biophysical Research Communications
Abstract
High levels of acrolein (H2CHCCHO) occur in Alzheimer’s brain. Amyloid-β (Aβ) peptide co-localizes with acrolein presumably due to Aβ-induced lipid peroxidation. Focal production of acrolein may yield a transient elevation in the concentration of acrolein that may be susceptible to polymerization via basic latex polymer chemistry. Following incubation of Aβ with acrolein (16–750 mM), we observed the formation of thin plastic fragments that were extensively punctuated. Planar aggregates stained for protein and for cross-β structures suggesting an Aβ-polyacrolein colloidal mixture. Depending on acrolein concentration and incubation time, we observed uniformly sized planar aggregates (approximately 10 μm2) or monolayers (>100 mm2) of thin polyacrolein films embedded with Aβ oligomers. The ability of Aβ to catalyze the polymerization of acrolein is likely due to Aβ’s surfactant and redox properties. These observations suggest that plastic in the form of Aβ-polyacrolein latexes may exist in neural tissue contributing to the pathogenesis of Alzheimer’s disease.
DOI
10.1016/j.bbrc.2005.07.111
Publication Date
9-2005
Keywords
Alzheimer’s disease, Amyloid beta-peptides, acrolein
ISSN
1090-2104
Recommended Citation
Seidler NW, Squire TJ. Aβ-Polyacrolein Aggregates: Novel Mechanism of Plastic Formation in Senile Plaques. Biochemical and Biophysical Research Communications. 2005; 335(2). doi: 10.1016/j.bbrc.2005.07.111.
