2-Chloro-2′-deoxyadenosine: Alteration of DNA:TATA Element Binding Protein (TBP) Interactions
Document Type
Article
Publication Title
Journal of Molecular Modeling
Abstract
2-Chloro-2′-deoxyadenosine (CldAdo, cladribine) is used therapeutically for hairy cell and other leukemias. The nucleoside is converted in leukemia cells to the 2-Cl-analog of dATP and incorporated into DNA, where it may alter binding of transcription factors to gene regulatory AT-rich sequences. Here we model the effects of CldATP incorporation into the adenovirus major late promoter TATA element recognized by TATA binding protein (TBP). The modeling results are consistent with experimental studies of DNA:TBP binding and indicate which positions in the canonical TATA sequence are most severely affected by CldATP incorporation.
DOI
10.1007/s00894-003-0163-8
Publication Date
2-2004
ISSN
0948-5023
Recommended Citation
Foley TT, Hentosh P, Walters D. 2-Chloro-2′-deoxyadenosine: Alteration of DNA:TATA Element Binding Protein (TBP) Interactions. Journal of Molecular Modeling. 2004; 10(1). doi: 10.1007/s00894-003-0163-8.
