Document Type

Abstract

Publication Title

The FASEB Journal

Abstract

Introduction

The brain and spinal cord are covered by dura mater which attaches to bones and muscles in the cervical region. Dural connective structures have been described as the Ligamentum Craniale Durae Matrice Spinalis (LCDMS) (Von Lanz, 1929). The myodural bridge complex (MBC) is a component of the LCDMS linking suboccipital musculature to the cervical spinal dura. While performing en bloc dissections of the central nervous system, we found a novel connection between the occiput and the cervical spinal dura that has not been previously described that we have termed, the ligamentum kryptos craniale (LKC). In this study, we provide evidence that the LKC is a previously unrecognized component of the LCDMS.

Methods

A total of 13 cadavers were dissected. Total spinal laminectomy and en bloc dissection was performed on two cadavers, and the occiput was removed via a coronal cut with inferior borders meeting the lateral most aspect of the foramen magnum. Eleven different cadaver skulls were cut at the euryon in transverse section. Five of the 11 cadavers were hemisected to the level of C5. LKC Length from origin to opisthion, thicknesses at opisthion, length from opisthion to cervical dura, and width at opisthion were measured. All measurements were taken with Mitutoyo Absolute IP-67 digital calipers except for LKC width, in which a flexible ruler was used. Photograph evidence was also obtained, and statistical analysis was conducted using Microsoft Excel.

Results

The LKC was found in all bodies (13 specimens). Its shape was triangular as it exited the foramen magnum and inserted onto the cervical spinal dura (Fig. 1). Its origin spanned across the internal occipital crest, the inferior ridge of the cerebellar fossa, and the opisthion (Fig. 2). Various measurements of the LKCs were made (expressed as means + SD) including the length from origin to opisthion (1.94 ± 0.3 cm, N = 10), thickness at opisthion (0.58 ± 0.05 mm, N = 6), length from opisthion to cervical dura (10.51 ± 2.59 mm, N = 5) and width at opisthion (5.05 ± 0.44 cm, N = 10).

Conclusion

Based on the findings of this study, we believe the LKC is a novel component of the LCDMS. Data suggests the MBC attaches to the LKC rather than directly to the cervical spinal dura mater. In the clinical setting, the LKC may be relevant to unknown causes of head and neck pain. Future histological studies and microscopic analysis will be necessary to further categorize this structure.

DOI

10.1096/fasebj.2021.35.S1.02502

Publication Date

5-2021

ISSN

1530-6860

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