Document Type
Article
Publication Title
Journal of the American Osteopathic Association
Abstract
A double-blind, crossover clinical trial was conducted to investigate the possible role of endorphins in the pain relief brought about-by osteopathic manipulative treatment (OMT) for low back pain. Twelve male patients who clinically demonstrated. painful limitation of movement at the level of the lumbar spine received OMT on two occasions, once after an intravenous dose of naloxone (10 mg.), and once after an intravenous dose of naloxone vehicle. Thirty minutes prior to drug treatment, the subject's limitation of movement and subjective pain were assessed. Following drug treatment and OMT, limitation of movement and subjective pain were assessed at regular intervals during a 2-hour period. The results revealed that the only significant pain relief observed was in the naloxone treatment group. These findings suggest the possibility that naloxone could in some way be contributing an analgesic effect in terms of the musculoskeletal pain being experienced by these patients.
DOI
10.1515/jom-1984-840934
Publication Date
9-1984
ISSN
1945-1997
Recommended Citation
Payson SM, Holloway HS. Possible Complications of Using Naloxone as an Internal Opiate Antagonist in the Investigation of the Role of Endorphins in Osteopathic Manipulative Treatment. Journal of the American Osteopathic Association. 1984; 84(1S). doi: 10.1515/jom-1984-840934.
