Nedocromil in the Outpatient Management of Asthma
Document Type
Article
Publication Title
Archives of Family Medicine
Abstract
Objective: To more closely approximate the use of a nonsteroidal inhaled anti-inflammatory medication for asthma, nedocromil sodium, under actual ambulatory practice conditions.
Design: Large, open-label trial.
Patients: One thousand two hundred one patients from 286 primary care and specialty centers.
Intervention: Four weeks of treatment with nedocromil sodium (4 mg delivered from the valve and 3.5 mg delivered from the mouthpiece of a metered inhalor [2 puffs, four times daily]).
Main outcome measures: Asthma symptom scores, peak expiratory flow rate, a lifestyle assessment measures questionnaire, and mean number of days missed per month from work or school.
Results: Statistically significant improvements were seen after 1 and 4 weeks of treatment for cough, daytime and nighttime asthma, morning tightness, peak expiratory flow rate, and all four measured lifestyle assessment factors (P < .001). An additional clinically relevant outcome measure, mean number of days missed per month from work or school, was reduced by 75% (P < .001). No serious adverse reactions were reported.
Conclusion: This study reproduces the high level of efficacy and safety of nedocromil that was previously reported in placebo-controlled clinical studies.
DOI
10.1001/archfami.4.10.835
Publication Date
10-1995
ISSN
1063-3987
Recommended Citation
Keenan JM, Bielory L, Flamion PC, Ford LB, Murcek M, Pyszczynski DR, Selcow J, Silvagni AJ, Tarpay M, Zitt MJ. Nedocromil in the Outpatient Management of Asthma. Archives of Family Medicine. 1995; 4(10). doi: 10.1001/archfami.4.10.835.
