Document Type
Article
Publication Title
SAGE Open Medical Case Reports
Abstract
This case study investigates the use of a 40-gene expression profile to independently predict the risk of metastasis in an immunocompromised 75-year-old male patient with cutaneous squamous cell carcinoma of his left cheek. The patient's previous medical history included non-melanoma skin cancer. Traditional staging methods, such as those from the American Joint Committee on Cancer 8th edition and Brigham and Women's Hospital, suggested a high risk of metastasis for this patient. However, the 40-gene expression profile test identified the patient as having a low risk (Class 1 result) of metastasis within 3 years. The patient successfully underwent Mohs surgery, and pathology was notable for positive perineural invasion of large caliber nerves. This case highlights the potential of the 40-gene expression profile as an independent predictor in assessing metastatic risk compared to traditional staging methods.
DOI
10.1177/2050313X241284141
Publication Date
9-25-2024
Keywords
Squamous cell carcinoma, cutaneous squamous cell carcinoma, nonmelanoma skin cancer, skin cancer, Mohs micrographic surgery
ISSN
2050-313X
Recommended Citation
Samman L, Fernandez C, Gomez-Meade C. 40-Gene Expression Profile Test Predicting Metastatic Risk in Localized, High-risk Cutaneous Squamous Cell Carcinoma for Peer Review. SAGE Open Medical Case Reports. 2024; 12. doi: 10.1177/2050313X241284141.
