Calcium Channel Blockers in Critical Care Medicine: Current Clinical Applications and Future Investigational Perspectives

Authors

• Akram M. Eraky, Kansas City University
• Yasser Mokhtar, Freeman Health System
• Guy Grabau, Freeman Health System
• Adnan Khan, Freeman Health System
• Ashish Acharya, SUNY Upstate Medical University
• Nichole Gadd, Freeman Health System
• Mark Jarosz, Freeman Health System
• Abhishek Premkumar, Freeman Health System

Document Type

Article

Publication Title

Medical Sciences

Abstract

Calcium channel blockers (CCBs) are frequently used in the emergency department and intensive care unit for a wide range of critical conditions, including atrial fibrillation, hypertensive emergencies, acute pulmonary edema with sympathetic crashing, pulmonary hypertension, and vasospastic syndromes. However, their toxicity can lead to significant hemodynamic compromise, underscoring the importance of understanding their pharmacologic effects and safety profile. This review summarizes the current applications of CCBs in critically ill patients, evaluates their safety in congestive heart failure, and highlights emerging therapeutic roles and recent advances in the management of CCB toxicity.

DOI

10.3390/medsci14020213

Publication Date

4-25-2026

Keywords

calcium channel blockers, atrial fibrillation, hypertensive emergencies, pulmonary hypertension, vasospasm, hypertensive emergency, CHF

ISSN

2076-3271

Recommended Citation

Eraky AM, Mokhtar Y, Grabau G, Khan A, Acharya A, Gadd N, Jarosz M, Premkumar A. Calcium Channel Blockers in Critical Care Medicine: Current Clinical Applications and Future Investigational Perspectives. Medical Sciences. 2026; 14(2). doi: 10.3390/medsci14020213.