Document Type

Article

Publication Title

Journal of Integrative Dermatology

Abstract

Background

The epithelial barriers, which include the skin, the gut, and the respiratory lining, play a crucial role in protecting the body from pathogens and environmental threats. Many harmful toxins are increasingly part of modern life. The increase in usage of these damaging agents in conjunction with the increase in allergic inflammatory conditions suggests that the “epithelial barrier hypothesis”—the concept that damage to the epithelia by external agents can result in dysbiosis, inflammation, and allergy—may explain the rise in these conditions seen in the developed world.

Objective

We sought to assess the evidence for the epithelial barrier hypothesis, with particular focus on the skin.

Methods

A systematic search of PubMed and Embase was performed using search terms relating to epithelial barriers and damaging agents.

Results

Our initial search yielded 25 results with 7 studies meeting inclusion criteria.

Limitations

Lack of studies.

Conclusions

The epithelial barrier hypothesis provides an understanding of mechanisms affecting the integrity of the skin, gut, and respiratory barriers that may lead to inflammation and allergic disease throughout the body.

Publication Date

12-24-2024

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