Chapter 14 - Role of T-cells in Immunotherapy of Pancreatic and Colon Cancers
Document Type
Book Chapter
Publication Title
Immune Therapy for Pancreatic and Colon Cancers
Abstract
Oncological immunotherapy is a rapidly growing discipline that aims to treat many tumors. It has demonstrated promising results in the early identification and management of cancer. Gastrointestinal (GI) cancers, including colon and pancreatic cancer, are among the major cancer-related deaths worldwide. Surgical procedures, chemotherapy, radiation therapy, targeted therapy, and immunotherapy are many treatment modalities that are currently accessible. Nevertheless, these treatments are accompanied by other limitations, including challenges in detecting patients at an advanced stage, developing resistance to treatment, and adverse effects on patients’ quality of life. CAR-T cell therapy specifically offers a promising approach for treating GI tumors by using the body's immune system to target cancer cells. Current research primarily focuses on selecting pertinent antigens, altering the tumor's microenvironment, and addressing toxicity control. Although initial findings show promise, further research is necessary to enhance the effectiveness of CAR-T cell therapy and revolutionize the treatment of GI tumors. Several ongoing clinical trials are exploring its efficacy. However, some challenges must be confronted, such as issues related to toxicity and safety. Future clinical research may benefit from focusing on improving hybrid antigens’ technical details to target specific tumor locations and checkpoints. This has the potential to enhance patient outcomes and increase the quality of life.
DOI
10.1016/B978-0-443-24742-2.00002-2
Publication Date
1-17-2025
ISBN
978-0-443-24742-2
Recommended Citation
Dudhia A, Rajan M, Patel K, Hafeez A, Lambring CB, Basha R. Chapter 14 - Role of T-cells in Immunotherapy of Pancreatic and Colon Cancers. Immune Therapy for Pancreatic and Colon Cancers. 2025; . doi: 10.1016/B978-0-443-24742-2.00002-2.
