Document Type
Article
Publication Title
JAAD Case Reports
Abstract
Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus typically found in middle-aged patients of color with dark brown or gray patches on sun-exposed areas such as the face, trunk, and upper extremities.1 A rarer variant is lichen planus pigmentosus inversus (LPPI), which, in contrast to LPP, more commonly affects Caucasians and has a predilection for intertriginous regions like the axillae, groin, abdominal folds, and antecubital and popliteal areas.2 Few case reports describe effective treatments for LPP, and even fewer on LPPI. Topical tretinoin and tacrolimus 0.1% ointment are the most commonly used treatments; however, responses vary.3 To our knowledge, this is the first report to demonstrate the detailed use and favorable effects of oral tranexamic acid (TXA) in improving hyperpigmentation in a patient with LPPI.
DOI
10.1016/j.jdcr.2025.07.037
Publication Date
12-2025
Keywords
lichen planus pigmentosus, lichen planus pigmentosus inversus, tranexamic acid
ISSN
2352-5126
Recommended Citation
Starzyk T, Zaki M, Remé B, Moon S. Oral Tranexamic Acid for Lichen Planus Pigmentosus Inversus: A Case Report of Therapeutic Success. JAAD Case Reports. 2025; 66. doi: 10.1016/j.jdcr.2025.07.037.
