Pediatric Neurodegenerative White Matter Processes: Leukodystrophies and Beyond
Pediatric neurodegenerative white matter processes are complex, numerous and result from a vast array of causes ranging from white matter injury or inflammation to congenital metabolic disorders. When faced with a neurodegenerative white matter process on neuroimaging, the first step for the radiologist is to determine whether the findings represent a congenital metabolic leukodystrophy or one of various other white matter processes. In this review we first describe a general approach to neurodegenerative white matter disorders. We will briefly describe a few white matter diseases that mimic metabolic leukodystrophies. In the second half of the review we discuss an approach to distinguishing and classifying white matter leukodystrophies
Phelan JA, Lowe LH, Glasier CM. Pediatric Neurodegenerative White Matter Processes: Leukodystrophies and Beyond. Pediatric Radiology. 2008; 38(7). doi: 10.1007/s00247-008-0817-x.