Document Type
Article
Publication Title
Frontiers in Endocrinology
Abstract
Background: Liver resection (LR) and local tumor destruction (LTD) are effective treatments, but not commonly recommended for patients with intermediate/advanced hepatocellular carcinoma (HCC). This study aimed to explore whether LR/LTD could improve overall survival (OS) of these patients, and to identify the patients who will most likely benefit from LR/LTD.
Methods: Data of patients with intermediate/advanced HCC between 2001 and 2018 were extracted from Surveillance, Epidemiology, and End Results database. OS was compared between HCC patients who received LR/LTD and those who did not. A nomogram was constructed for predicting OS, and it was then validated.
Results: A total of 535 eligible patients were included, among which 128 received LR/LTD while 407 did not. Significantly higher OS in patients who received LR/LTD was observed (P<0.001). Based on independent prognostic factors obtained from univariate and multivariate analyses, a nomogram was constructed. The C-indices of nomogram were higher than those of the TNM staging system (training cohort: 0.74 vs. 0.59; validation cohort: 0.78 vs. 0.61). Similarly, areas under receiver operating characteristic curves and calibration curves indicated good accuracy of the nomogram. Decision curve analysis curves revealed good clinical practicability of the nomogram. Furthermore, low-risk patients (nomogram score: 0-221.9) had higher OS compared with high-risk patients (nomogram score: higher than 221.9) (P<0.001).
Conclusion: LR/LTD significantly improves OS in patients with intermediate/advanced HCC. The nomogram developed in the present study shows high predicating value for OS in patients with intermediate/advanced HCC, which might be useful in selecting patients who are most suitable for LR/LTD.
DOI
10.3389/fendo.2023.1191822
Publication Date
7-28-2023
Keywords
liver resection, local tumor destruction, hepatocellular carcinoma, survival, nomogram
ISSN
1664-2392
Recommended Citation
Zhang Y, Zhang Y, He T, Liu G, Duan M, Huang J, Huang C, Lowe S, Ke D, Liu X, Cao J. Local Tumor Destruction and Liver Resection Increase Overall Survival in Intermediate/Advanced Hepatocellular Carcinoma Patients: Evidence From a Population-Based Study. Frontiers in Endocrinology. 2023; 14. doi: 10.3389/fendo.2023.1191822.
