Document Type
Article
Publication Title
Human Genomics
Abstract
Congenital heart defects (CHD) are the most common cause of death in children under the age of 1. Tetralogy of Fallot (TOF) is a severe CHD that results from developmental defects in the conotruncal outflow tract. Recently, a tissue-specific gene expression template (GET) was derived from microarray data that accurately characterized multiple normal human tissues. We used the GET to examine spatial, temporal, and a pathological condition (TOF) within a single organ, the heart. The GET, as previously defined, generally identified temporal and spatial differences in the cardiac tissue. Differences in the stoichiometry of the GET reflected the severe developmental disturbance associated with TOF. Our analysis suggests that the homoeostatic equilibrium assessed by the GET at the inter-organ level is generally maintained at the intra-organ level as well.
DOI
10.1186/1479-7364-8-6
Publication Date
3-11-2014
Keywords
Gene expression template, Congenital heart defect, Tetralogy of Fallot
ISSN
1479-7364
Recommended Citation
Rodemoyer A, Kibiryeva N, Bair A, Marshall J, O'Brien JE, Bittel D. A Tissue-Specific Gene Expression Template Portrays Heart Development and Pathology. Human Genomics. 2014; 8. doi: 10.1186/1479-7364-8-6.
