Intravascular Lymphomatosis With Bone Marrow Involvement: A Case Report and Review of the Literature
Document Type
Article
Publication Title
Archives of Pathology and Laboratory Medicine
Abstract
We describe the case of a 56-year-old man who presented with numbness and tingling of the extremities, weakness, and fatigue. Laboratory findings included anemia and thrombocytopenia. A diagnosis of intravascular lymphomatosis was established when liver, omentum, and bone marrow samples were examined. A review of the literature reveals that most cases of intravascular lymphomatosis have cytopenias, mainly anemia and thrombocytopenia, but bone marrow involvement is rare. In our case, a subtle neoplastic infiltrate in the marrow sinusoids was highlighted with a B-cell marker. While immunohistochemical analysis was not performed in most reported cases in the literature, our studies suggest that a systematic search in bone marrow of cases of intravascular lymphomatosis may reveal unsuspected neoplastic cells. We conclude that bone marrow involvement in intravascular lymphomatosis appears to be rare, has subtle features, and is difficult to diagnose if unsuspected and not searched for.
DOI
10.5858/1999-123-0952-ILWBMI
Publication Date
10-1-1999
ISSN
1543-2165
Recommended Citation
Tucker TJ. Intravascular Lymphomatosis With Bone Marrow Involvement: A Case Report and Review of the Literature. Archives of Pathology and Laboratory Medicine. 1999; 123(10). doi: 10.5858/1999-123-0952-ILWBMI.
