Document Type

Article

Publication Title

Cureus

Abstract

Nivolumab targets programmed cell death protein 1 (PD-1) and is used in cancer treatment by increasing the immune response. It has rarely been associated with immune-mediated colitis (IMC). We present a 66-year-old man with metastatic lung adenocarcinoma, treated with nivolumab for seven years, who developed tenesmus and mucoid bloody diarrhea. Colonoscopy revealed endoscopic and histopathological ulcerative colitis (UC)-like changes, limited to the distal 25cm of the colon. Although nivolumab-induced IMC resembling UC is a known adverse effect, there are very few reports of nivolumab-induced IMC localized to the distal colon and occurring seven years after treatment initiation.

DOI

10.7759/cureus.72373

Publication Date

10-25-2024

Keywords

distal colon, immune-checkpoint inhibitors, immune-mediated colitis, late onset, nivolumab, ulcerative colitis

ISSN

2168-8184

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