Illuminating the Use of Photodynamic Therapy in Urologic Oncology

Document Type

Article

Publication Title

Canadian Journal of Urology

Abstract

Introduction: We report the first scoping review of the clinical urologic literature for photodynamic therapy (PDT) among multiple urologic malignancies.

Materials and methods: A scoping review using Medline and Embase was performed for treatment of urologic malignancies with PDT.

Results: There were 84 papers included with the majority involving bladder and prostate cancer. Upper tract urothelial cancer (UTUC) only comprised three publications and there was no clinical data for renal or testicular cancer. Utilizing PDT in prostate cancer led to a negative biopsy rate of 30%-100%. Bladder cancer treatment with PDT had a 3-month complete response rate of 31.5%-100%. UTUC management with PDT reported at least 50% complete response rate.

Conclusions: Ultimately, PDT has been established as a safe and effective treatment for urologic malignancies and we provide the first comprehensive review of the literature regarding the utility of this treatment modality.

Publication Date

12-2024

Keywords

erectile dysfunction, hematoporphyrin derivative, hematuria, photochemotherapy, photodynamic therapy, prostatic neoplasm, quality of life, urinary bladder neoplasms, urinary incontinence

ISSN

1195-9479

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