Bumps on My Head-A Case of Acute T-Cell Lymphoblastic Lymphoma
Document Type
Article
Publication Title
American Journal of Dermatopathology
Abstract
T-cell lymphoblastic lymphoma (T-LBL) is an aggressive, rare neoplasm of immature T-cell precursors, typically presenting with lymphadenopathy, a mediastinal mass, and bone marrow involvement. We report the case of a 25-year-old man who presented with plaques and subcutaneous nodules on the scalp, forehead, and left cheek, accompanied by posterior cervical lymphadenopathy. Immunohistochemical studies of intralesional punch, lymph node, and bone marrow biopsies confirmed a diagnosis of T-LBL. In addition, NOTCH1 oncogene mutations, a common feature of T-LBL, were detected. Although cutaneous involvement in T-LBL is rare and uncommonly the most prominent symptom, this case highlights a rare presentation with predominantly cutaneous manifestations. This emphasizes the importance of early recognition when malignancy is suspected to prevent the development of more severe complications.
DOI
10.1097/DAD.0000000000003081
Publication Date
7-28-2025
Keywords
T-cell lymphoblastic lymphoma, cutaneous T-LBL, lymphadenopathy, mediastinal mass
ISSN
1533-0311
Recommended Citation
Brambert L, Bhukhan A, Dukharan V, Mitropoulos P, Marks E. Bumps on My Head-A Case of Acute T-Cell Lymphoblastic Lymphoma. American Journal of Dermatopathology. 2025; . doi: 10.1097/DAD.0000000000003081.
