Document Type

Article

Publication Title

Cureus

Abstract

Dendritic cell neurofibroma with pseudorosettes (DCNP) is an exceedingly rare neurofibroma variant presenting as scattered, isolated, skin-colored papules or nodules primarily on the trunk. It consists of clusters of smaller type I cells with dark nuclei and inconspicuous cytoplasm, surrounded by much larger type II cells with abundant cytoplasm and vesicular nuclei containing pseudoinclusions, resulting in the formation of distinctive pseudorosettes. While unique, it can be misdiagnosed as other neural tumors due to its histologic and clinical similarities. This report presents a unique case of DCNP in a 34-year-old male with a longstanding, asymptomatic 1.3 cm pink nodule on his mid-chest, initially suspected to be a neurofibroma. This case, along with surgical excision and histopathologic evaluation, provides valuable insight into the diagnosis of DCNP, highlighting the need for increased recognition of this rare entity and encouraging further research to refine diagnostic criteria and management strategies.

DOI

10.7759/cureus.90796

Publication Date

8-23-2025

Keywords

dendritic cell neurofibroma with pseudorosettes (dcnp), dermato-pathology, histopathology, neural tumors differential diagnosis, pseudorosettes

ISSN

2168-8184

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