Beta-thioglucose Inhibits Gold Thioglucose Lesions in the Ventromedial Hypothalamus
Document Type
Article
Publication Title
Physiology & Behavior
Abstract
Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabolite, on GTG-induced lesions in the VMH of mice. Twenty-eight female CF-1 mice were used in this study. Seven micron sections were made of the mouse VMH, mounted on glass slides, and stained with hematoxylin and eosin. A previous report of BTG action on GTG-induced lesions has not supported a competitive inhibition between these two drugs. Our data demonstrate that at 1/2 hour, 6 hours, and 12 hours post BTG, BTG completely inhibited GTG-induced lesions in the VMH.
DOI
10.1016/0031-9384(89)90005-x
Publication Date
9-1989
ISSN
1873-507X
Recommended Citation
Brown DF, McGuirk JP, Larsen SP, Minter SD. Beta-thioglucose Inhibits Gold Thioglucose Lesions in the Ventromedial Hypothalamus. Physiology & Behavior. 1989; 46(3). doi: 10.1016/0031-9384(89)90005-x.
